Stem Cell China · Han's United
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Treatment methods · stem cells

How we treat with stem cells — in plain words

Below — without scientific jargon — we explain which cells we use, how we deliver them, who benefits, and when this therapy is not right.

Cell types
3
Routes of administration
5
Treatment areas
6
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In brief · one minute read

What stem cells actually are

Stem cells are the body's universal "repair" cells. Unlike ordinary heart, liver or muscle cells, they have not yet committed to a single role.

When an organ is damaged — by a stroke, a heart attack or diabetes — a stem cell can become the tissue type that's needed and help recovery. At the same time it reduces inflammation and reactivates the body's own "dormant" cells.

We use young stem cells together with their signalling particles — exosomes. We deliver them to the right part of the body in five different ways and choose the route that works best for the specific diagnosis.

Three sources of cells

Which cells exactly we use

Three types of biomaterial with different mechanisms of action. The specific choice depends on the diagnosis and is selected individually.

  • UC-MSC

    Umbilical cord mesenchymal stem cells

    The youngest and most active cells. Suitable for most patients — they hardly trigger an immune reaction, because they are not yet "marked" by age.

    In plain words

    • Where from

      From the tissue of the umbilical cord of healthy newborns — after a planned caesarean section and with the parents' written consent.

    • What it does

      Differentiates into the needed tissue, reduces inflammation, and reactivates the body's own cells.

    • Where it goes

      Into the bloodstream via an IV drip, or into the cerebrospinal fluid via a thin needle.

    Scientific definition

    Young multipotent cells isolated from Wharton's jelly of the umbilical cord. High proliferative activity and low immunogenicity.

  • P-MSC

    Placental mesenchymal stem cells

    Most effective in autoimmune conditions — where the immune system attacks the patient's own tissues.

    In plain words

    • Where from

      From the placenta immediately after birth — normally the placenta is discarded; we use it for medical purposes.

    • What it does

      Strongly calms an over-active immune system and reduces autoimmune aggression.

    • Where it goes

      Mostly into the bloodstream via an IV drip in systemic inflammatory conditions.

    Scientific definition

    Placenta-derived cells with pronounced immunomodulatory potential. Used in autoimmune and inflammatory conditions.

  • Exosomes

    Stem cell exosomes

    A modern non-invasive route — therapy can continue at home between procedures.

    In plain words

    • Where from

      These are not cells but tiny "messages" sent out by stem cells — about 200 times smaller than a cell.

    • What it does

      They carry signalling molecules that "instruct" the body's cells how to repair themselves.

    • Where it goes

      Uniquely — as nasal drops they enter the brain directly through the nose, bypassing barriers.

    Scientific definition

    Extracellular vesicles 30–150 nm in size carrying signalling molecules. Capable of crossing the blood-brain barrier.

Map · where each method works

Where we deliver the cells

Stem cells can be administered in different ways — through the bloodstream, into the cerebrospinal fluid, directly into a damaged joint, or as nasal drops. The route is chosen by the physician based on the diagnosis, the goal of treatment, and the patient's condition.

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  • Through an IV drip (intravenous)

    Cells travel throughout the body via the bloodstream. The most studied and broadly applicable route. Suitable for most diagnoses.

    More below

  • Into the spinal canal

    A thin needle in the lower back under local anaesthesia — cells reach the brain and spinal cord directly. Used for cerebral palsy, stroke, Parkinson's disease.

    More below

  • Targeted (into the affected area)

    A direct injection into the affected joint, muscle or damaged tissue. When the highest cell concentration is needed in one zone — for example, knee osteoarthritis.

    More below

  • Nasal drops (exosomes)

    Through the olfactory nerve, the "messages" from cells reach the brain — no needle, no hospitalisation. Therapy can continue at home between procedures.

    More below

  • Two routes combined

    An IV drip plus a spinal injection in one trip — for severe neurological cases. Prescribed by the academic board.

    More below

Five routes of administration

Exactly how the cells are delivered

From systemic intravenous infusion to precise intrathecal delivery into the CNS. The route is dictated by the diagnosis, not by preference.

  1. 01

    Intravenous — through an IV drip

    The most studied and widely used route. Cells distribute throughout the body via the bloodstream, delivering a powerful systemic effect.

    What the terms mean

    Immunomodulation
    Restoring the balance of the immune system — neither suppressing nor over-activating it.
    Systemic effect
    An effect on the whole body at once, not on a single area.

    What to know

    • Immunomodulation and reduction of inflammatory processes
    • Activation of the body's dormant stem cells
    • Suitable for autoimmune, endocrine and cardiovascular conditions
    • Course of 3 procedures spaced 15–20 days apart
    UC-MSCP-MSC
  2. 02

    Into the spinal canal — for direct delivery to the nervous system

    Cells are injected directly into the subarachnoid space via lumbar puncture. The goal is to bypass the blood-brain barrier and deliver cells into the central nervous system.

    What the terms mean

    Subarachnoid space
    A thin layer of fluid around the brain and spinal cord — the route through which cells reach the nervous system.
    Lumbar puncture
    A thin needle inserted into the lower back under local anaesthesia. The same procedure used to sample cerebrospinal fluid.
    BBB (blood-brain barrier)
    A protective filter between blood and brain. Most drugs cannot cross it — the intrathecal route bypasses it.

    What to know

    • Cells reach the CNS directly, bypassing the blood-brain barrier
    • A CP or ASD diagnosis alone is not a basis for choosing this administration route
    • Used for stroke recovery and traumatic brain injury
    • The procedure takes 30–45 minutes under local anaesthesia
    UC-MSC
  3. 03

    Locally — targeted into the affected organ or joint

    Direct injection into a specific organ or damaged tissue. Used when maximum cell concentration in the affected area is required.

    What the terms mean

    Intra-articular injection
    An injection straight into the joint cavity — for example, the knee or hip.
    Intramuscular injection
    An injection straight into the muscle — for tissue recovery after injury.

    What to know

    • Intra-articular — for osteoarthritis and joint disorders
    • Localised injection — for spinal cord injuries
    • Intramuscular — for muscle tissue recovery
    • Targeted regenerative effect in a specific area
    UC-MSCP-MSC
  4. 04Innovation

    Nasal exosomes — drops in the nose instead of an injection

    An advanced non-invasive method. Exosomes pass through the olfactory and trigeminal nerves directly into the brain — no needle, no hospitalisation, delivered as nasal drops.

    What the terms mean

    Olfactory nerve
    The nerve responsible for smell. It runs from the nose straight into the brain — so exosomes reach the nervous system without a needle.
    Trigeminal nerve
    A large facial nerve — the second pathway through which exosomes reach the brain.
    Neuroinflammation
    Chronic inflammation in the nervous system — a common driver behind the progression of brain diseases.

    What to know

    • Safe direct entry into the brain via neural pathways
    • Nerve cell regeneration and suppression of neuroinflammation
    • Therapy can continue at home between procedures
    • Complements intrathecal administration or used on its own
    Exosomes
  5. 05

    Combined course — two routes in a single trip

    A combination of two routes for maximum effect. Most often intravenous administration for systemic support plus intrathecal for direct CNS impact.

    What the terms mean

    Academic board
    A group of 3–5 leading clinicians and scientists who make decisions on complex cases collectively.

    What to know

    • Most effective approach for severe neurological disorders
    • Systemic immunomodulation plus direct CNS regeneration
    • Dosage and intervals are calculated individually
    • Prescribed by the academic board based on diagnostic findings
    UC-MSCP-MSCExosomes

These technologies operate under the oversight of regulators on three continents.

  • NMPA filing

    NMPA Drug Application Acknowledgement — umbilical-cord MSC injection

  • ANSM · France

    ANSM (France) Clinical Trial Authorization

  • ISO 9001:2015

    ISO 9001:2015 — Bureau Veritas (English version)

All 45 documents

Six clinical fields

Where these methods apply

Six main areas where Hanshi United has accumulated experience. Every case is reviewed individually by the academic board.

Neurology

Who it suits

Information for discussing a neurological condition with a clinician. Cell-based interventions for CP and autism remain investigational; listing a diagnosis here does not establish an indication for a procedure.

The most common application of cell therapy. Stem cells and exosomes help restore nerve cells, reduce inflammation in the brain, and improve connections between neurons. They are particularly effective when intravenous and spinal delivery are combined.

  • Stroke
  • Alzheimer's and dementia
  • Parkinson's
  • autism
  • cerebral palsy
  • epilepsy
See detailed protocols for each diagnosis

  • Cardiology

    Who it suits

    For patients with myocardial infarction, ischaemic heart disease, or heart failure.

    Myocardial infarction, ischaemic heart disease, heart failure, dilated cardiomyopathy

  • Endocrinology

    Who it suits

    For patients with Type 1 or Type 2 diabetes, particularly when early complications appear.

    Type 1 and Type 2 diabetes, diabetic complications

  • Gastroenterology

    Who it suits

    For patients with liver fibrosis or cirrhosis, Crohn's disease, or ulcerative colitis.

    Liver cirrhosis and fibrosis, liver failure, Crohn's disease, ulcerative colitis

  • Orthopaedics

    Who it suits

    For patients with osteoarthritis, avascular necrosis, or fractures that heal slowly.

    Osteoarthritis, avascular necrosis of the femoral head, osteoporosis, delayed fracture healing

  • Autoimmune disorders

    Who it suits

    For patients with lupus, rheumatoid arthritis, scleroderma, or severe psoriasis.

    Systemic lupus erythematosus, rheumatoid arthritis, psoriasis, scleroderma

Detailed information on each diagnosis is available in the Treatments section.

Important · Contraindications

When cell therapy is not the right fit — four cases

The conditions below either preclude cell therapy or require particular caution. The final decision is made by a physician after a full examination.

  • Active oncological conditions

    Stem cells can stimulate the growth of existing tumours through growth factors and angiogenesis.

    What to do

    First complete the full course of oncology treatment and achieve stable remission (typically 5+ years). After that we are ready to review your case — cell therapy can speed up recovery after chemotherapy or radiotherapy.

  • Acute infectious diseases

    During an active infection, cell therapy can worsen the condition and reduce the effectiveness of the body's own immune response.

    What to do

    Wait until you have fully recovered and your test results have returned to normal. This is a matter of weeks, not years — once you have recovered, the contraindication no longer applies and we can begin therapy.

  • Pregnancy and breastfeeding

    The effect of stem cell therapy on the foetus and the breastfed infant has not been studied in clinical trials.

    What to do

    There is no safe alternative during pregnancy — but after the birth and the end of breastfeeding you are welcome to contact us again.

  • Severe coagulation disorders

    Any injectable cell-administration route carries a bleeding risk when haemostasis is impaired. Prior correction is required.

    What to do

    Discuss the coagulation disorder with the treating clinician and a haematologist. Normalisation of individual test results does not by itself establish the safety of a cell intervention. A decision needs individual assessment and details of the specific product and route; no universal eligibility timeline is set here.

Is this suitable for your case?

Tell us your story — the academic board will review your questionnaire and within 24-48 hours will draft a personal plan: which cells, which route, and what course.

Get a consultation

Medical questionnaire · 10–15 min

Speed up your consultation

If you are ready to share the medical history and documents in advance, please fill out the detailed questionnaire. This helps the academic board prepare a personal protocol before the first conversation.

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